Asymmetric synthesis of benzoxazinones

Details Asymmetric synthesis of benzoxazinones Asymmetric synthesis of benzoxazinones

1997-04-11

1999-08-03

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 71, 544 92, 549388, 564384, 564392, 564442, 564389, C07D26516, C07D26518

Patent

active

059327260

ABSTRACT:
The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

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