Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl

Details Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl

1998-04-15

2000-10-17

Leary, Louise N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 2710

Patent

active

061334855

ABSTRACT:
The asymmetric production of pure diastereomeric (2R,3R), (2R,3S), (2S,3R) and (2S,3S)-2-aryl-1-substituted butan-2,3-diols from the derivatives of lactic acid.

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Konosu, et al., Chem Pharm. Bull. 39(9) 2241-2246 (1991), "Triazole Antifungals. III. Stereocontrolled Synthesis of an Optically Active Triazolymethyloxirane Precursor to Antifungal Oxazolidine Derivatives".
Tasaka, et al., Chem. Pharm. Bull. 41(6) 1035-1042 (1993), "Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-buta nol and Its Stereoisomers".
Tasaka, et al., Chem. Pharm. Bull. 45(2) 321-326 (1997), "Optically Active Antifungal Azoles. VII. Synthesis and Antigungal Activity of Stereoisomers of 2-[1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2-4-triazol-1- yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolo ne (TAK-187)".
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