Asymmetric reduction of 1,1,1-trifluoroacetone

Details Asymmetric reduction of 1,1,1-trifluoroacetone Asymmetric reduction of 1,1,1-trifluoroacetone

2007-03-27

2007-03-27

Parsa, J. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

Reexamination Certificate

active

11478821

ABSTRACT:
The invention relates to a scalable biocatalytic process for the preparation of S-1,1,1-trifluoro-2-propanol with a enantiomeric excess of >99% by asymmetric microbial reduction of 1,1,1-trifluoroacetone with Baker's yeast.

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Bucciarelli M., et al., Synthesis (1983) 11, pp. 897-899.
Dahl A. C. et al., Tetrahedron: Asymmetry (1999) 10, pp. 551-559.
Yasohara Y., et al., Appl. Microbiol. Biotechnol. (1999) 51: 847-851.
Yang, Z.-H., et al., Ind. Eng. Chem. Res. (2004) vol. 43, pp. 4871-4875.
Nakamura, K. et al., Tetrahedron: Asymmetry (1996), vol. 7, pp. 409-412.

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