Asymmetric ligands useful for transition metal catalyzed bond fo

Details Asymmetric ligands useful for transition metal catalyzed bond fo Asymmetric ligands useful for transition metal catalyzed bond fo

1995-06-07

1998-04-14

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548412, 548482, 549 6, 549 57, 549216, 549468, 549469, 549470, C07F 928, C07F 950

Patent

active

057393966

ABSTRACT:
Ligands useful for transition metal catalyzed bond forming reactions are provided with a metal binding portion having at least one metal binding moiety ##STR1## wherein Ar and Ar' each is an aryl or a heteroaryl. These ligands may be prepared by providing an aromatic carboxylic acid having a diarylphosphino or diheteroarylphosphino substituent on the aromatic ring, and forming an ester or an amide derivative of the carboxylic acid by coupling with a chiral diol or a chiral diamine. The ligands facilitate, for example, flexible strategies for enantiocontrolled construction of five membered carbocyclic rings with varying substitution patterns and high enantioselectivity.

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