Asymmetric hydrogenation process using ruthenium-diphosphine com

Details Asymmetric hydrogenation process using ruthenium-diphosphine com Asymmetric hydrogenation process using ruthenium-diphosphine com

1996-07-26

1998-05-12

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544224, 544235, 5483561, 5483601, 5483631, 5483794, 540496, 540500, 540553, 540567, C07D23726, C07D23704, C07D23104

Patent

active

057506906

ABSTRACT:
A process for the asymmetric hydrogenation of a compound of the formula ##STR1## wherein each R, independently, is alkyl, arylmethyl, aryl, alkoxy, arylmethoxy or aryloxy or both R's, taken together, are methylene, ethylene or 1,2-phenylene and n is 1,2 or 3,
or of a salt thereof to a compound of the formula ##STR2## in the form of an (S) or (R) enantiomer, wherein R and n have the significances given above, using an optically active ruthenium-diphosphine complex as catalyst, is described. The preparation of the compounds of formula II, as well as the compounds of formula II, which form a further object of the invention, are also described.

REFERENCES:
patent: 4331818 (1982-05-01), Riley
patent: 4512924 (1985-04-01), Attwood et al.
patent: 4556740 (1985-12-01), Hansen et al.
Bevan et al, J. Chem. Soc. pp. 514-522, 1971.
Adams et al, Synthetic Communications 18 pp. 2225-2231, 1988.
Tetr.Lett. 29 Nr. 46, 5969-5972 (1988) Hayashi et al.
Liebigs Ann Chem 1974, 1391-1398 (Bormann).
Chem. and Ind. Feb. 1, 1964 p. 193 (Loev).
J. Gen. Chem. USSR 29, 95-99 (1959) (Kost et al.).
Helv. Chim. Acta 61, Fasc 4(1988) No. 135, 1364-1372 (Schiess et al.).
J. Chem. Soc. Chem Commun 1989, 1208-1210 (K. Mashima et al.).
Abstract (corresponding to EP398 132) Nov. 22, 1990.
Advanced Organic Chemistry (2nd Ed.) by Jerry Mar., pp. 92-94 (1977).
Noyori et al. Acc. Chem. Res. 23:345-350 (1990).
Abstract of JP 55061937-May 11, 1980.

Affiliated with

Also associated with

Rating

Asymmetric hydrogenation process using ruthenium-diphosphine com does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Asymmetric hydrogenation process using ruthenium-diphosphine com, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Asymmetric hydrogenation process using ruthenium-diphosphine com will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-980233