Asymmetric hydrogenation of furoimidazole derivatives

Details Asymmetric hydrogenation of furoimidazole derivatives Asymmetric hydrogenation of furoimidazole derivatives

1994-08-03

1995-07-18

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483027, 5483017, 5483001, C07D491048, C07D491044

Patent

active

054342694

ABSTRACT:
A process for the asymmetric hydrogenation of furoimidazole derivatives of the general formula: ##STR1## with hydrogen in the presence of a homogeneous catalyst to give the corresponding diastereomeric dihydrofuroimidazole derivatives of the general formula: ##STR2## R.sub.1 and R.sub.2 are protective groups, although R.sub.2 can be hydrogen. The dihydrofuroimidazole derivatives of the general formula II are intermediates for the preparation of (+)-biotin.

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T. Hayashi et al., Bull. Chem. Soc. Japan, 53, (1980), pp. 1138-1151.
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Giordano et al., Inorg. Synth., 19, (1979), pp. 218 to 220.
Noyori et al, Acc. Chem. Res 1990, 23, pp.345 to 350 (Oct. 1990).

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