Asymmetric hydrogenation of furoimidazole derivatives

Details Asymmetric hydrogenation of furoimidazole derivatives Asymmetric hydrogenation of furoimidazole derivatives

1994-05-09

1995-09-19

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D491048

Patent

active

054516846

ABSTRACT:
A process for the asymmetric hydrogenation of furoimidazole derivatives of the general formula: ##STR1## wherein R.sub.1 is a protective group and R.sub.2 is hydrogen or a protective group, with hydrogen in the presence of a homogeneous catalyst to give the corresponding diastereomeric dihydrofuroimidazole derivatives of the general formula: ##STR2## The dihydrofuroimidazole derivatives of the general formula II are intermediates for the preparation of the vitamin (+)-biotin.

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