Asymmetric hydrogenation of dihyrofuroimidazole derivatives

Details Asymmetric hydrogenation of dihyrofuroimidazole derivatives Asymmetric hydrogenation of dihyrofuroimidazole derivatives

1997-07-22

1998-05-26

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49148

Patent

active

057567565

ABSTRACT:
A process for the asymmetric hydrogenation of the furoimidazole derivatives of the general formula: ##STR1## wherein R.sub.1 is a protective group, which is cleavable in a known way, and R.sub.2 is hydrogen or a protective group, which is cleavable in a known way, with hydrogen in the presence of a homogeneous catalyst to the corresponding diastereomeric tetrahydrofuroimidazole derivatives of the general formula: ##STR2## The tetrahydrofuroimidazole derivatives of the general formula II are intermediate products for the production of vitamin (+) biotin.

REFERENCES:
patent: 4851540 (1989-07-01), McGarrity
patent: 4876350 (1989-10-01), McGarrity
patent: 4937351 (1990-06-01), Poetsch
patent: 5162540 (1992-11-01), McGarrity
patent: 5235065 (1993-08-01), Schuarz
M. Fiorini et al., J. Mol. Catal., 5, (1979), 303 and M. Fiorini et al., J. Mol. Catal., 7, (1980), 411.
J. Chatt et al., J. Chem. Soc., (1957), 4735.
G. Giordano et al., Inorg. Synth., 19, (1979), 218.
McOmie, Protective Groups in Organic Chemistry p. 63, (1973).

Affiliated with

Also associated with

Rating

Asymmetric hydrogenation of dihyrofuroimidazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Asymmetric hydrogenation of dihyrofuroimidazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Asymmetric hydrogenation of dihyrofuroimidazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1962196