Asymmetric hydrogenation of dihydrofuroimidazole derivatives

Details Asymmetric hydrogenation of dihydrofuroimidazole derivatives Asymmetric hydrogenation of dihydrofuroimidazole derivatives

1995-07-13

1997-03-11

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

502213, C07D491048, C07D49504, C07D23502, C07D40302, B01J 27105

Patent

active

056103123

ABSTRACT:
A process for the asymmetric hydrogenation of the furoimidazole derivatives of the general formula: ##STR1## wherein R.sub.1 is a protective group, which is cleavable in a known way, and R.sub.2 is hydrogen or a protective group, which is cleavable in a known way, with hydrogen in the presence of a homogeneous catalyst to the corresponding diastereomeric tetrahydrofuroimidazole derivatives of the general formula: ##STR2## The tetrahydrofuroimidazole derivatives of the general formula II are intermediate products for the production of vitamin (+) biotin.

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