Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-08-10
1978-09-19
Konopka, P. E.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
252429R, 252431P, 260DIG44, 2604109R, 2606065P, 260690, C11C 312, C07F 950, C07B 100
Patent
active
041154177
ABSTRACT:
A method for the homogeneous catalytic enantioselective hydrogenation of alkyl and alkenyl substituted acrylic acids wherein these acids are selectively hydrogenated at the double bond alpha, beta to the acid function, said hydrogenations are catalyzed by rhodium complexes of chiral tertiary phosphines. This method provides a route to chiral dihydrogeranic acid and other intermediates useful in the synthesis of chiral vitamin E, citronellal, and menthol. Novel chiral tertiary phosphines are also disclosed.
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Journal of the American Chemical Society -- 93, 3/10/71 "Asymmetric Homogeneous Hydrogenation . . .", Morrison, J. D. et al., pp. 1301-1303.
Hoffmann-La Roche Inc.
Johnston George W.
Konopka P. E.
Leon Bernard S.
Welt Samuel L.
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