Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols

Details Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols

1999-02-09

2000-02-15

Richter, Johann

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

548217, C07D26308

Patent

active

060251778

ABSTRACT:
Processes for preparing a single enantiomer of an .alpha.,.alpha.-disubstituted-.alpha.-hydroxy acetic acid, especially cyclohexylphenylglycolic acid (CHPGA), is disclosed. The processes employ cyclic 1,2-aminoalcohols as chiral auxiliaries by forming diastereomeric esters of aminoalcohols or diastereomeric amides of oxazolidines. ##STR1## Intermediates useful in the process are also disclosed.

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