Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols

Details Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols

1998-03-30

2000-01-11

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548217, 548498, C07C 6976, C07D26354

Patent

active

060138300

ABSTRACT:
Processes for preparing a single enantiomer of an .alpha.,.alpha.-disubstituted-.alpha.-hydroxy acetic acid, especially cyclohexylphenylglycolic acid (CHPGA), is disclosed. The processes employ cyclic 1,2-aminoalcohols as chiral auxiliaries by forming diastereomeric esters of aminoalcohols or diastereomeric amides of oxazolidines. ##STR1## Intermediates useful in the process are also disclosed.

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