Asymmetric catalysis

Details Asymmetric catalysis Asymmetric catalysis

1983-07-08

1985-05-07

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604654, 560 24, 560757, C07C12178

Patent

active

045157316

ABSTRACT:
Catalytic asymmetric hydrogenation of the Z geometric isomer of a compound of the formula ##STR1## wherein at least one of R and R.sup.1 represents hydrogen and the other represents hydrogen, lower alkyl or aryl; R.sup.2 represents ##STR2## wherein R.sup.4 and R.sup.5 each independently represent hydrogen, lower alkyl or aryl, R.sup.6 represents hydrogen, lower alkyl, aryl or an alkali metal; and R.sup.3 represents ##STR3## wherein R.sup.7 and R.sup.8 each independently represent lower alkyl or aryl; provided that, when R.sup.3 is ##STR4## R.sup.2 is --CN, in the presence of a homogeneous, coordination complex catalyst comprising rhodium, iridium or ruthenium in combination with an optically active bis phosphine ligand provides an outstanding level of optical purity.

REFERENCES:
patent: 4008281 (1977-02-01), Knowles et al.
Vineyard et al., J.A.C.S., vol. 99, 5946, (1977).
Morrison et al., J.A.C.S., vol. 93, 1301, (1971).
Kagan et al., J. Organometallic Chem., vol. 90, 353, (1975).

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