Asymmetric bioreduction of 6-bromo-2-tetralone to (s)-6-bromo-2

Details Asymmetric bioreduction of 6-bromo-2-tetralone to (s)-6-bromo-2 Asymmetric bioreduction of 6-bromo-2-tetralone to (s)-6-bromo-2

1994-06-24

1995-11-07

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435280, 435911, C12P 722, C12P 4100

Patent

active

054647622

ABSTRACT:
Stereospecific (S)-6-bromo-2-tetraol is a key intermediate in the chemical synthesis of the chiral drug candidate, MK499, a ventricular arrythmias suppressant. The yeast strain Trichosporon capitatum (MY 1890) was employed for the bioconversion of 6-bromo-2-tetralone to the corresponding alcohol.

REFERENCES:
ATCC Catalogue of Filamentous Fungi, pp. 79, 440 (1991).
ATCC Catalogue of Yeasts, pp. 46, 96, 164 (1990).

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