Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones

Details Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones

1983-11-25

1985-01-29

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260376, C07C 5027

Patent

active

044964854

ABSTRACT:
This invention relates to novel diastereomeric 7-O-(substituted acetyl)-4-demethoxydaunomycinones that are useful in the preparation of optically pure 4-demethoxydaunorubicin, a drug used in the treatment of certain cancers.

REFERENCES:
patent: 4046878 (1977-09-01), Patelli et al.
patent: 4077988 (1978-03-01), Arcamone et al.
patent: 4161480 (1979-07-01), Garland et al.
C. M. Wong et al., Synthetic Studies of Hydronaphthacenic Antibiotics, I. Synthesis of 4-Demethoxy-7-O-methyl Daunomycinone Can. J. Chem., 49, 2712, (1971).
S. Terashima et al., Asymmetric Synthesis of Optically Active Anthracyclinones, Tetrahedron Lett., 4937, (1978).
F. Arcamone et al., Synthesis and Antitumor Activity of 4-Demethoxydaunorubicin, 4-Demethoxy-7,9-diepidaunorubicin, and Their B Anomers. Cancer Treat. Rep., 60, 829, (1976).

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