Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1978-05-04
1979-08-07
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
A61K 3536, A61K 3900
Patent
active
041637780
ABSTRACT:
Significant decreases in bronchial sensitivity to cat dander in patients who experience asthmatic symptoms on exposure to cats are achieved by subjecting the patient to immunotherapy employing various dilutions of a cat dander extract containing at least 10% (based on total solids content) cat allergen 1 and, when undiluted, at least 300 micrograms/ml cat allergen 1. Cat allergen 1 is an antigen having a molecular weight between 30,000 and 60,000 daltons. It is identifiable by its ability to form a precipitin line with allergen 1 antiserum. A double blind, rigorously controlled study of the immunotherapy process has demonstrated that significant reductions in bronchial sensitivity may be routinely obtained in asthmatics of this class.
REFERENCES:
ohman, Kendall, and Lowell, J. Allergy Clin. Immunol., 60(5): 317-323, Nov. 1977, IgE Antibody to Cat Allergens in an Allergic Population.
Ohman, Lowell, Bloch, and Kendall, Clinical Allergy, 6: 419-428, (1976), Allergens of Mammalian Origin V. Properties of Extracts Derived from the Domestic Cat.
Stokes and Turner, Clinical Allergy, 5: 241-254 (1975), Isolation and Characterization of Cat Allergens.
Ohman, Bloch, Kendall, and Lowell, J. Allergy Clin. Immunol., 57: 560-568 (1976), Allergens of Mammalian Origin IV. Evidence for Common Allergens in Cat and Dog Serum.
Ohman, Lowell, and Bloch, J. Immunol., 113: 1668 (1974), Allergens of Mammalian Origin III. Properties of a Major Feline Allergen.
Ohman, Lowell, and Bloch, J. Allergy Clin. Immunol., 52(4): 231-241, Oct. 1973, Allergens of Mammalian Origin: Characterization of Allergen Extracted from Cat Pelts.
Holford-Strevens, Clin. Allergy, 3: 225-234 (1973), Allergenic Activity of Cat and Dog Skin Fractions Obtained by Sephadex Gel Filtration.
Varga and Ceska, Int. Arch. Allergy, 42: 438-453 (1972), Characterization of Allergen Extracts by Polyacrylamide Gel Isoelectrofocusing and Radioimmunosorbent Allergen Assay II. Dog and Cat Allergens.
Lowell Francis C.
Ohman John L.
Rose Shep K.
The Foundation for the Study of Asthma and Related Diseases
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