Assymetric hydrogenation of isoprene derivatives

Details Assymetric hydrogenation of isoprene derivatives Assymetric hydrogenation of isoprene derivatives

1995-05-19

1997-02-04

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568596, 568875, 568903, C07C 4562

Patent

active

056000154

ABSTRACT:
There is described a process for the manufacture of isoprene derivatives of the general formula ##STR1## wherein the asymmetric centres can each individually have the (R)- or (S)-configuration, R represents a residue of the formulae ##STR2## R.sup.1 signifies lower alkyl or both R.sup.1 's together signify ethylene or propylene and n stands for the number 0, 1 or 2,
in which a compound, which is present in the (E)- or (Z)-form, of the general formula ##STR3## wherein R, n and an optionally present asymmetric centre have the above significance,
is asymmetrically hydrogenated with a ruthenium complex of an optically active atropisomeric diphosphine.

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patent: 5132464 (1992-07-01), Rossiter et al.
Inoue et al Chem. Letters, (1985), p. 1007-8.
Broger et al, Chem. Abst, vol. 114, #164,034n (1991).
Ohta et al, J. Org. Chem, vol. 52, pp. 3174-3176 (1987).

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