Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-10-01
1998-11-03
Railey, II, Johnny F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, C12N 1512
Patent
active
058310576
ABSTRACT:
The invention pertains to a novel gene present in cytological region 37D of the second chromosome which functions in associative learning and/or memory. Disruption of the gene, such as by P element transposon-tagged insertion, results in decreased associative learning and/or memory. The invention also pertains to a novel protein encoded by the gene, antibodies which bind the encoded protein, and homologs of the novel gene which function in associative learning and hybridize to the DNA sequence of the novel gene.
REFERENCES:
DeZazzo and Tully, "Dissection of Memory Formation: From Behavioral Pharmacology To Molecular Genetics", Trends Neurosci., 18(5):212-217 (1995).
Hammer and Menzel, "Learning and Memory in the Honeybee", J. Neurosci., 15(3):1617-1630 (1995).
Tully, T., et al., "Genetic Dissection of Memory Formation in Drosophila Melanogaster", Cold Spring Harbor Symp. Quant. Biol., 55:203-211 (1990).
Davis and Squire, "Protein Synthesis and Memory: A Review", Psychological Bulletin, 96(3):518-559 (1984).
Castellucci, V.F., et al., "Inhibitor of Protein Synthesis Blocks Long-Term Behavioral Sensitization in the Isolated Gill-Withdrawal Reflex of Aplysia", J. of Neurobio., 20(1): 1-9 (1989).
Crow and Forrester, "Inhibition of Protein Synthesis Blocks Long-Term Enchancement of Generator Potentials Produced by One-Trial in vivo Conditioning in Hermissenda", Proc. Natl. Acad. Sci., USA, 87:4490-4494 (1990).
Tully, T., et al., "Genetic Dissection of Consolidated Memory in Drosophila", Cell, 79:35-47 (1994).
Carew, T.J., et al., "Long-Term Habituation of a Defensive Withdrawal Reflex in Aplysia", Science, 175:451-454 (1972).
Frost, W., et al., "Monosynaptic Conncections Made by the Sensory Neurons of the Gill- and Siphon-Withdrawal Reflex in Aplysia Participate in the Storage of Long-Term Memory for Sensitization", Proc. Natl. Acad. Sci. USA, 82:8266-8269 (1985).
Huang, Y-Y., et al., "Recruitment of Long-Lasting and Protein Kinase A-dependent Long-Term Potentiation in the CA 1 Region of Hippocampus Requires Repeated Tetanization", Learning and Memory 1:74-82 (1994).
Alberini, C., et al., "C/EBP Is An Immediate-Early Gene Required for the Consolidation of Long-Term Facilitation in Aplysia", Cell 76:1099-1114 (1994).
Bourtchuladze, R., et al., "Deficient Long-Term Memory in Mice with a Targeted Mutation of the cAMP-Responsive Element-Binding Protein", Cell, 79:59-68 (1994).
Yin, J. C. P., et al., "Induction of a Dominant Negative CREB Transgene Specifically Blocks Long-Term Memory in Drosophila", Cell, 79:49-58 (1994).
Tully and Quinn, "Classical Conditioning and Retention in Normal and Mutant Drosophila Melanogaster", J. Comp. Physiology A 157:263-277 (1985).
Tully and Gold, "Differential Effects of Dunce Mutations on Associative Learning and Memory in Drosophila", J. Neurogenetics, 9:55-71 (1993).
Boynton and Tully, "latheo, a New Gene Involved in Associative Learning and Memory in Drosophila Melanogaster, Identified from P Element Mutagenesis"Genetics, 131:655-672 (1992).
Dura, J. -M., et al., "Identification of Linotte, A New Gene Affecting Learning and Memory in Drosophila Melanogaster", J. Neurogenetics, 9:1-14 (1993).
Ewer, J., et al., "An Inducible Promoter Fused to the Period Gene in Drosophila Conditionally Rescues Adult Per-Mutant Arrhythmicity", Nature, 333:82-84 (1988).
Dauwalder and Davis, "Conditional Rescue of the dunce Learning/Memory and Female Fertility Defects with Drosophila or Rat Transgenes", J. of Neuroscience, 15(5) :3490-3499 (1995).
Hawkins and Kandel, "Is There A Cell-Biological Alphabet for Simple Forms of Learning?", Psychological Review, 91(3) :375-391 (1984).
Davis, R., "Mushroom Bodies and Drosophila Learning", Neuron, 11:1-14 (1993).
Bliss and Collingridge, "A Synaptic Model of Memory: Long-Term Potentiation in the Hippocampus," Nature, 361:31-39 (1993).
Bryne J., et al., "Roles of Second Messenger Pathways in Neuronal Plasticity and in Learning and Memory", Advances in Second Messenger and Phosphoprotein Research, 27:47-108 (1993).
Maurice Dura, J. et al., "The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product", FEBS Letters 370:250-254 (1995).
DeZazzo and Tully, "Dissection of memory formation: from behavioral pharmacology to molecular genetics", TINS 18 (5) :212-218 (1995).
Bolwig, G. et al., "Molecular Cloning of linotte in Drosophila: A Novel Gene That Functions in Adults during Associative Learning", Neuron 15:829-842 (1995).
Bolwig Gert M.
Tully Timothy
Cold Spring Harbor Laboratory
Railey II Johnny F.
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