Association of kinensin with sensitivity to chemotherapeutic dru

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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4351723, 4353201, 435325, 435375, 536 231, 536 245, C12Q 168, C12N 516, C12N 1510, C07H 2100

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058663274

ABSTRACT:
The invention provides genetic suppressor elements that confer upon a cell resistance to one or more chemotherapeutic drug, methods for identifying and obtaining such elements, and methods of using such elements. The invention also provides cloned genes associated with sensitivity to chemotherapeutic drugs, particularly a cloned human kinesin heavy chain gene involved in resistance to DNA damaging agents.

REFERENCES:
patent: 5217889 (1993-06-01), Roninson et al.
patent: 5665550 (1997-09-01), Roninson et al.
Lau and Nathans, 1985, "Identification of a set of genes expressed during the GO/G1 transition of cultured mouse cells", EMBO J. 4: 3145-3151.
Chen et al., 1986, "Internal Duplication and Homology with Bacterial Transport Proteins in the mdr1 (P-Glycoprotein) Gene from Multidrug-Resistant Human Cells", Cell 47: 381-389.
Lau and Nathans, 1987, "Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc", Proc. Natl. Acad. Sci. USA 84: 1182-1186.
Vale, 1987, "Intracellular transport using microtubule-based motors", Ann. Rev. Cell Biol. 3: 347-378.
Markowitz et al., 1988, "Construction and Use of a Safe and Efficient Amphotropic Packaging Cell Line", Virology 167: 400-406.
Ohara et al., 1989, "One-sided polymerase chain reaction: the amplification of cDNA", Proc. Natl. Acad. Sci. USA 86: 5673-5677.
Albrittion et al., 1989, "A Putative Murine Ecotropic Retrovirus Receptor Gene Encodes a Multiple Membrane-Spanning Protein and Confers Susceptibility to Virus Infection", Cell 57: 659-666.
Noonan et al., 1990, "Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction", Proc. Natl. Acad. Sci. USA 87: 7160-7164.
Kung et al., 1990, "Cytotosic Effects of Cell Cycle Phase Specific Agents: Result of Cell Cycle Perturbation", Cancer Res. 50: 7307-7317.
Uhlmann and Peyman, 1990, "Antisense Oligonucleotides: A New Therapeutic Principle", Chemical Reviews 90: 543-584.
Schneider and Banner, 1990, "Building blocks for oligonucleotide analogs with dimethylene-sulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages", Tetrahedron Letters 31: 335.
Bodine et al., 1990, "Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells", Proc. Natl. Acad. Sci. USA 87: 3738-3742.
McDonald & Goldstein, 1990, "Identification and Characterization of a Gene Encoding a Kinesin-like Protein in Drosophila", Cell 61: 991-1000.
Kosik et al., 1990, "The Primary Structure and Analysis of the Squid Kinesin Heavy Chain", J. Biol. Chem. 265: 3278-3283.
Baim et al., 1991, "A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl .beta.-D-thiogalactopyranoside", Proc. Natl. Acad. Sci. USA 88: 5072-5076.
Patanjali et al., 1991, "Construction of a uniform-abundance (normalized) cDNA library", Proc. Natl. Acad. Sci. USA 88: 1943-1947.
Endow, 1991, "The emerging kinesin family of microtubule motor proteins", Trends Biochem. Sci. 16: 221-225.
Cyr et al., 1991, "Molecular genetics of kinesin light chains: Generation of isoforms by alternative splicing", Proc. Natl. Acad. Sci. USA 88: 10114-10118.
Holzmayer et al., 1992, "Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments", Nucleic Accids. Res. 20: 711-717.
Culver et al., 1992, "In Vivo gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors", Science 256: 1550-1552.
Navone et al., 1992, "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtublues in transfected CV-1 cells", J. Cell Biol. 117: 1263-1275.
Perry et al., 1992, "Induction of gene amplification by 5-aza-2'-deoxycytidine", Mutation Res. 276: 189-197.
Gauger and Goldstein, 1993, "The Drosophila Kinesin Light Chain", J. Biol. Chem. 268: 13657-13666.
Gudkov et al., 1993, "Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA", Proc. Natl. Acad. Sci. USA 90: 3231-3235.
Groger, et al. 1989. "Directional antisense and sense cDNA cloning using Epstein-Barr virus episomal expression vectors." Gene 81:285-294.
Lock, et al. 1988. "Differential patterns of anti-tumor drug responses and mechanisms of resistance in a series of independently-derived VP-16-resistant human tumour cell lines." Int. J. Cancer 42(3):371-381.
Shen, et al. 1986. "Human multidrug-resistant cell lines: Increased mdr1 expression can precede gene amplification." Science 232:643-645.
Tsai-Pflugfelder, et al. 1988. Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc. Natl. Acad. Sci. USA 85:7177-7181.
Ferreira et. al. (1991) Soc. for Neurosci. Abstr. 17(1-2), 58.
Ferreira et. al. (1992). J Cell Biol 117(3), 595-606.
Nielsen et. al. (1991) Sci. 254, 1497-1500.
Yalowich (1987) Cancer Res. 47, 1010-1015.
Sczakiel, G. et al. Jun. 15, 1990. Specific inhibition of human immunodeficiency virus type 1 replication by RNA transcribed in sense and antisense orientation from the 5'-leader/gag region, Bioch. Biophys. Res. Comm. 169 (2):643-651.
Friedman, A.D. et al. Sep. 29, 1988, "Expression of a truncated viral transactivator selectively impedes lytic infection by its cognate virus", Nature 335:452-454.
Napoli, C., et al. Apr., 1990, "Introduction of a chimeric chaclone synthase gene into petunia results in reversible co-suppression of homologus genes in trans", The Plant Cell 2(4):279-289.
Kidd, V.J., et al. Dec. 4, 1990, "Dominant negative mutation in galactosyltransferase created by over-expression of a truncated cDNA", Chemical Abstracts 111(23):225-234.
Baird, L., et al. Mar. 1990, "Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) Null phenotype", Journal of Bacteriology 172(3):1587-1594.

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