Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-08-28
2007-08-28
Ewoldt, G. R. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S007100
Reexamination Certificate
active
10393870
ABSTRACT:
The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
REFERENCES:
patent: WO99/54351 (1999-10-01), None
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Busch C.P. et al., Genetic Determinants Of Type 2 Diabestes Mellitus, Clin. Genet, (2001), vol. 60, pp. 243-254.
Franco Rendrik F. et al., Genetic Risk Factors Of Venous Thrombosis, Human Genetics, (2001), vol. 109, pp. 369-384.
MacLennan A.J. et al., Edg5, A Human Homolog Of Rat H218 That Is A Functional Receptor For Lysosphingolipids, Database Accession No. AF034780, XP002227241 Abstract.
MacLennan A. John et al., Cloning And Characterization Of A Putative G-Protein Coupled Receptor Potentially Involved in Development, Molecular and Cellular Neurosciences, (1994), vol. 5, No. 5, pp. 210-219.
Sesti Giorgio, Insulin Receptor Substrate Polymorphisms And Tye 2 Diabetes Mellitus, Pharmacogenomics, (2000(, vol. 1, No. 3, pp. 343-357.
Deleuze Jean-Francois
Jacobs Martina
Kostenis Evi
Kozian Detlef
Mace Sandrine
Ewoldt G. R.
Juedes Amy
Krupen Karen I.
Sanofi-Aventis Deutschland GmbH
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