Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-02-15
2011-02-15
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S024100, C536S024330
Reexamination Certificate
active
07888020
ABSTRACT:
The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
REFERENCES:
GenBank Accession No. AF034780 (www.ncbi.com Jan. 1, 1999).
Niedernberg et al. (Biochemical Pharmacology 2002 VOI 63 p. 1243).
Perrier et al. (Chest vol. 118 Nov. 2000 p. 1234).
Busch C.P. et al., Genetic Determinants of Type 2 Diabetes Mellitus, Clin. Genet, (2001), vol. 60), pp. 243-254.
Franco Rendrik F. et al., Genetic Risk Factors of Venous Thrombosis, Human Genetics, (2001), vol. 109, pp. 369-384.
Kuppermann et al., Accession No. Q918K8, 2006.
MacLennan A.J. et al., Edg5, A Human Homolog of Rat H218 That is a Functional Receptor For Lysosphingolipids, Database Accession No. AF034780, XP002227241 Abstract.
MacLennan A. John et al., Cloning and Characterization of a Putative G-Protein Coupled Receptor Potentially Involved in Development, Molecular and Cellular Neurosciences, (1994), vol. 5, No. 5, pp. 210-219.
Sesti Giorgio, Insulin Receptor Substrate Polymorphisms and Tye 2 Diabetes Mellitus, Pharmacogenomics, (2000), vol. 1, No. 3, pp. 343-357.
Deleuze Jean-Francois
Jacobs Martina
Kostenis Evi
Kozian Detlef
Mace Sandrine
Bausch Sarae
Fontenot J. Darrell
Salmon Katherine
Sanofi-Aventis Deutschland GmbH
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