Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Reexamination Certificate
2003-04-04
2009-11-17
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
C514S562000, C560S143000
Reexamination Certificate
active
07618955
ABSTRACT:
The present invention relates to a new combination of an antithrombotic and aspirin and to pharmaceutical compositions comprising them.
REFERENCES:
patent: 5472979 (1995-12-01), Lavielle et al.
patent: 0648741 (1995-04-01), None
Helgason, et al., “Inhibition of Platelet aggregation by aspirin alone and by aspirin in combination with clopidogrel: synergy, incompatibility and additivity” IEEE, 2000, p. 215-217. http://ieeexplore.ieee.org/iel5/7041/18959/00877423.pdf.
B. Cimetiere, et al., New Tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors, Bioorganic & Medicinal Chemistry Letters, vol. 8, 1998, pp. 1381-1386.
B. Cimetiere, et al., “Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists”, Bioorganic & Medicinal Chemistry Letters, vol. 8, No. 11, Jun. 2, 1998, pp. 1375-1380.
S. Simonet, et al., “S 18886, A new thromboxane (TP)-receptor antagonist is the active isomer of S 18204 in all species, except in the Guinea-Pig”, Advances in Experimental Medicine and Biology, vol. 433, 1997, pp. 173-176.
A. Cayatte, et al., “The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis”, Arteriosclerosis Thrombosis and Vascular Biology, vol. 20 No. 7, Jul. 2000, pp. 1742-1728.
Cimetiere Bernard
Lavielle Gilbert
Vallez Marie-Odile
Verbeuren Tony
Hueschen and Sage
Javanmard Sahar
Les Laboratoires Servier
Padmanabhan Sreeni
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