Surgery – Diagnostic testing – Cardiovascular
Reexamination Certificate
2005-07-12
2010-06-08
Bockelman, Mark W (Department: 3766)
Surgery
Diagnostic testing
Cardiovascular
C600S484000, C600S534000, C600S536000
Reexamination Certificate
active
07734334
ABSTRACT:
An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same.
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Goldberger Ary L.
Mietus Joseph E.
Peng Chung-Kang
Thomas Robert J.
Beth Israel Deaconess Medical Center Inc.
Bockelman Mark W
Sterne Kessler Goldstein & Fox P.L.L.C.
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