Surgery – Diagnostic testing – Cardiovascular
Reexamination Certificate
2008-01-29
2008-01-29
Bockelman, Mark (Department: 3766)
Surgery
Diagnostic testing
Cardiovascular
Reexamination Certificate
active
07324845
ABSTRACT:
An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.
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Goldberger Ary L.
Mietus Joseph E.
Peng Chung-Kang
Thomas Robert J.
Beth Israel Deaconess Medical Center
Bockelman Mark
Sterne Kessler Goldstein & Fox P.L.L.C.
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