Assessment of oxidative stress in vivo

Details Assessment of oxidative stress in vivo Assessment of oxidative stress in vivo

1998-02-24

1999-04-06

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 29, 435 25, C12Q 100, C12Q 126, C12Q 102

Patent

active

058916229

ABSTRACT:
A method to assess oxidative stress in vivo by measuring the amount of free, esterified and glucuronidated forms of isoprostanes (8EPGF2) in a biological sample which contains the isoprostanes is disclosed. The method further includes determining the amount of total isoprostanes present in the sample. This amount is compared with a control sample. The oxidative stress is determined through the comparison wherein the amount of isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control. Alternatively the method of the present invention provides for only the measurement of the glucuronidated form wherein the amount of glucuronidated isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control.

REFERENCES:
patent: 5700654 (1997-12-01), Roberts et al.
Awad et al: Hepatology, vol. 22(3), pp. 962-968, (1995) (Abstract).

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