Assessing heart failure in patients with atrial fibrillation...

Chemistry: analytical and immunological testing – Peptide – protein or amino acid

Reexamination Certificate

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C436S063000

Reexamination Certificate

active

07955854

ABSTRACT:
Disclosed are a method, device, and test kit for diagnosing heart failure in a patient exhibiting atrial fibrillation. The method includes determining an amount of growth differentiation factor-15 (GDF -15) in a sample from the patient and comparing the amount of GDF-15 determined with a reference amount of GDF-15, wherein when the amount of GDF-15 determined is greater than the reference amount of GDF-15, a diagnosis of heart failure is indicated.

REFERENCES:
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patent: 2008/015254 (2008-02-01), None
patent: 2009/027514 (2009-03-01), None
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Kempf, Tibor et al., The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury, Circulation Research, 2006, pp. 351-360, vol. 98.
Kempf, Tibor et al., Growth Differentiation Factor (GDF)-15 Protects the Heart from Ischemia/Reperfusion Injury in vivo, Supplement to Circulation, Abstracts from Scientific Sessions, Oct. 25, 2005, p. II-281, vol. 122, No. 17.
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