Assays utilizing sensitizer-induced production of detectable sig

Details Assays utilizing sensitizer-induced production of detectable sig Assays utilizing sensitizer-induced production of detectable sig

1992-12-01

1996-05-14

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 436537, 436546, 436 94, 436905, 536 243, 536 2532, 536 266, 935 76, 935 77, 935 78, C12Q 168, G01N 33542, G01N 3300, C12N 1500

Patent

active

055166369

ABSTRACT:
Specific binding assays are disclosed which utilize a sensitizer as a label. Such sensitizers include any moiety which, when stimulated by "excitation" with radiation of one or more wavelengths or other chemical or physical stimulus (e.g., electron transfer, electrolysis, electroluminescence or energy transfer), will achieve an excited state which (a) upon interaction with molecular oxygen will produce singlet molecular oxygen, or (b) upon interaction with a leucodye will assume a reduced form which can then be returned to its original unexcited state by interaction with molecular oxygen resulting in the production of hydrogen peroxide. Either interaction with the excited sensitizer will, with the addition of other reagents, produce a detectable signal.

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Fenical, et al., The Journal of the American Chemical Society, vol. 91, No. 12, Jun. 4, 1990, pp. 3396-3398.

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