Assays using TRAF2-associated protein kinase polypeptides

Details Assays using TRAF2-associated protein kinase polypeptides Assays using TRAF2-associated protein kinase polypeptides

1996-07-10

1999-02-23

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 17, 435194, C12N 912, C12Q 148

Patent

active

058742301

ABSTRACT:
A TRAF2 (Tumor Necrosis Factor receptor Associated Factor-2) kinase and DNA encoding it are described. The invention provides assays employing the TRAF2 kinase which are useful to identify candidate modulators of TRAF2-dependent signaling pathways.

REFERENCES:
Frohman, M. in PCR Protocols: A Guide to Methods and Applications (1990) Innis, et al eds. pp. 28-38, Academic Press, Inc. San Diego, Calif.
Cheng et al. Isolation and mapping of human chromosome 21 cDNA. Genomics 23, 75, 1994.
Kentrup et al. (1996) J. Biol. Chem. 271, 3488-3495; "Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity is Dependent on Tyrosine Residues between Subdomains VII and VIII"; see Figures 1 and 2 for sequence data.

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