Assays using chemiluminescent electron-rich aryl-substituted 1,2

Details Assays using chemiluminescent electron-rich aryl-substituted 1,2 Assays using chemiluminescent electron-rich aryl-substituted 1,2

1995-05-09

1999-12-14

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436523, 436526, 436535, 436543, 436544, 436547, 436548, 435 4, 435 6, 435 71, 435 72, 435 74, 435 78, 435 794, 549215, 549219, 549220, 549221, 25230116, 25230121, 25230133, 252700, G01N 33533

Patent

active

060016590

ABSTRACT:
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescent count, thus providing for a sensitive and precise assay for haptens, analytes, polynucleotides and the like. These substituted aryl-containing 1,2-dioxetane compounds can be used as direct labels in an immunoassay or when derivatized with an appropriate leaving group, can be used as a substrate for a enzyme immunoassay. The unusual chemiluminescence of the compounds allows the timing of the luminescent reaction to be exactly controlled.

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Gosling, James, A Decade of Development in Immunoassay Methodology 3618, 1408-1427, 1990.

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