Assays using a soluble fibrin-like monomer

Details Assays using a soluble fibrin-like monomer Assays using a soluble fibrin-like monomer

1995-06-06

2000-06-13

Spiegel, Carol A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 71, 435 771, 435 681, 436 69, 530382, 530407, C12Q 156, G01N 3353

Patent

active

060748370

ABSTRACT:
An assay method that requires a soluble fibrin monomer or a soluble fibrin monomer reagent as one of the components of the assay. The reagent is a fibrin-like material having a solubility and stability similar to fibrinogen in that it remains soluble and stable at physiological conditions at a concentration employed in the assay in the absence of fibrin polymerization inhibitors or reagents for maintaining solubility.

REFERENCES:
patent: 4429040 (1984-01-01), Becker et al.
patent: 4647554 (1987-03-01), Jolles et al.
patent: 4818690 (1989-04-01), Paques
Procyk, R. et al, "Disulfide Bond Reduction in Fibrinogen: Calcium Protection and Effect on Clottability", Biochemistry, 1990, 29, pp. 1501-1507.
Roman Procyk et al., Biochemistry, 1992, 31 2273-2278.
Clin. Chem. 32/3, 482-485 (1986).

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