Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2011-07-12
2011-07-12
Gross, Christopher M (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S015000, C506S011000
Reexamination Certificate
active
07977043
ABSTRACT:
An assay for use in high-throughput screening of chemical libraries to determine whether compounds in such libraries will inhibit CD38 catalytic activity, and CD38 production of ADPR and cADPR.
REFERENCES:
patent: 6599711 (2003-07-01), Crouch et al.
patent: 2003/0064394 (2003-04-01), Ohtake et al.
Perraud et al. Journal of Biological Chemistry. vol. 278(3): 1794-1801; Jan. 17, 2003.
David L. Clapper et al; “Pyridine Nucleotide Metabolites Stimulate Calcium Release from Sea Urchin Egg Microsomes Desensitized to Inositol Trisphosphate”; The Journal of Biological Chemistry; vol. 262, No. 20, Issue of Jul. 15, pp. 9561-9568, 1987; The American Society of Biological Chemists, Inc., USA.
Deepak A. Deshpande et al; “CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness”; The FASEB Journal; Mar. 2003; pp. 452-454; vol. 17.
Richard M. Graeff, et al; “High Throughput Fluorescense-Based Assays for Cyclic ADP-Ribose, NAADP, and Their Metabolic Enzymes”; Combinatorial Chemistry and High Throughput Screening; vol. 6;, No. 4; Jun. 2003; pp. 367-379; Bentham Science Publishers.
Richard M. Graeff, et al; “Enzymatic Synthesis and Characterizations of Cyclic GDP-Ribose”; The Journal of Biological Chemistry; vol. 269, No. 48, Issue of Dec. 2, pp. 30260-30267, 1994; The American Society for Biochemistry and Molecular Biology, Inc., USA.
Haruhiro Higashida, et al; “Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes”; Biochem J. (2000), 352, pp. 197-202; 2000 Biochemical Society; Great Britain.
Helene M. Muller-Steffner et al; “Slow-binding Inhibition of NAD+ Glycohydrolase by Arabino Analogues of B-NAD+”; The Journal of Biological Chemistry; vol. 267, No. 14, Issue of May 15, pp. 9606-9611, 1992; The American Society of Biochemistry and Molecular Biology, Inc., USA.
Santiago Partida-Sanchez et al; “Regulation of Dendritic Cell Trafficking by the ADP-Ribosyl Cyclase CD38: Impact on the Development of Humoral Immunity”; Immunity, vol. 20, pp. 279-291, Mar. 2004, Cell Press.
Santiago Partida-Sanchez et al; “Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose”; The Journal of Immunology, 2004, 172, pp. 1896-1906; The American Association of Immunologists, Inc., USA.
Anne-Laure Perraud et al; “ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology”; Nature, vol. 411, pp. 595-599; May 31, 2001; Macmillan Magazines Ltd.
Yorikata Sano et al; “Immunocyte Ca2+ Influx System Medicated by LTRPC2”; Science Magazine; Aug. 17, 2001; vol. 293, No. 5533, pp. 1327-1330; Science Magazine.
Katherine A Wall et al; “Inhibition of the intrinsic NAD+ glychohydrolase activity of CD38 by carbocyclic Nad analogues”; Biochem J. (1998) 335, pp. 631-636, Great Britain.
Singh, Pirthipal, Identification of Kinase Inhibitors by an ATP Depletion Method; Assay and Drug Development Technologies, vol. 2, No. 2, 2004 pp. 161-169.
Lukas Susan
Peet Gregory Whitten
Werneburg Brian
Boehringer Ingelheim International GmbH
Gross Christopher M
Lazer Edward S.
Morris Michael P.
LandOfFree
Assays useful in determining CD38 inhibition does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assays useful in determining CD38 inhibition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assays useful in determining CD38 inhibition will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2693451