Assays to screen for compounds that bind the dorsal root...

Details Assays to screen for compounds that bind the dorsal root... Assays to screen for compounds that bind the dorsal root...

2007-09-18

2007-09-18

Li, Ruixiang (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007920, C435S007930, C435S006120

Reexamination Certificate

active

10399181

ABSTRACT:
The present invention is directed to assays that can be used to screen for compounds that act as agonists or antagonists or inverse agonists of bovine adrenal medulla docosapeptide (BAM-22P). The assays are based upon the binding of BAM-22P to the rat and human DRR receptors.

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Thomas Walther et al. “Sustained Long Term Potentiation and Anxiety in Mice Lacking the Mas Protooncogene,” The Journal of Biological Chemistry, May 8, 1998, p. 11867-11873, vol. 273 (No. 19), The American Society for Biochemistry and Molecular Biology, Inc., U.S.A.
Paola Lembo et al., “Proenkephalin A Gene Products Activate a New Family of Sensory Neuron-Specific GPCRs”, Nature Neuroscience, Mar. 2002, pp. 201-209, vol. 5, No. 3, Nature Publishing Group.

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