Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1995-12-08
1998-06-02
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 6, C12Q 102
Patent
active
057597987
ABSTRACT:
The invention provides assays, kits and bacteria useful for detection of autoinducers. In a preferred aspect, the assay comprises 1) contacting a test sample suspected of containing an autoinducer with bacteria of the invention that are capable of producing an elevated amount of light in the presence of an exogenous autoinducer and that has at least two distinct genetic alterations that can each inhibit production of endogenous autoinducers; and 2) measuring the production of light. The sample will test positive for the presence of an autoinducer if a greater amount of light is produced relative to a control. The assays and kits have a variety of applications including use as an in vitro diagnostic for animal and plant disorders.
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Buckley Linda M.
Corless Peter F.
Housel James C.
Lowen Cara Z.
Portner Ginny Allen
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