Assays of cells expressing human calcium channels containing .al

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 72, 435 721, 435 691, C12Q 102, C12N 1512

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058769587

ABSTRACT:
Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.

REFERENCES:
patent: 4788135 (1988-11-01), Davis et al.
patent: 4912202 (1990-03-01), Campbell et al.
patent: 4954436 (1990-09-01), Froehner et al.
patent: 5024939 (1991-06-01), Gorman
patent: 5051403 (1991-09-01), Miljanich et al.
patent: 5189020 (1993-02-01), Miljanich et al.
patent: 5264371 (1993-11-01), Miljanich et al.
patent: 5424218 (1995-06-01), Miljanich et al.
Powers, et al., "Assignment of the human gene for the .alpha..sub.1 subunit of the cardiac DHP-sensitive Ca.sup.2+ channel (CCHL1A1) to Chromosome 12p12-pter," Genomics 10:835-839 (1991).
Kim, et al., "IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels," Science 239:405-408 (1988).
Claudio, et al., "Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts," Science 238:1688-1694 (1987).
Tanabe, et al., "Primary structure of the receptor for calcium channel blockers from skeletal muscle," Nature 328:313-318 (1987).
Vaghy, et al., "Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations," J. Biol. Chem. 262(29):14337-14342 (1987).
Nakayama, et al., "Purification of a putative Ca.sup.2+ channel protein from rabbit skeletal muscle," J. Biol. Chem. 262:6572-6576 (1987).
Leung, et al., "Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca.sup.2+ channel from rabbit skeletal muscle," J. Biol. Chem. 262(17):7943-7946 (1987).
Sharp, et al., "Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor," J. Biol. Chem. 62(25):12309-12315 (1987).
Takahashi, et al., "Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle," Proc. Natl. Acad. Sci. (USA) 84:5478-5482 (1987).
Morton et al. "Monoclonal antibody identifies a 200-kDA subunit of the dihydropyridine-sensitive calcium channel," J. Biol. Chem. 262(25):11904-11907 (1987).
Barhanin, et al., "The calcium channel antagonists receptor from rabbit skeletal muscle: reconstitution after purification and subunit characterization," Eur. J. Biochem. 164:525-531 (1987).
Sieber, et al., "The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel," Eur. J. Biochem. 167:117-122 (1987).
Lang, et al., "The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse," J. Physiol. 390:257-270 (1987).
Curran and Morgan, "Barium modules c-fos expression and post-translational modification," Proc. Natl. Acad. Sci. 83:3521-8524 (1986).
Fisch, et al., "c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate, and the calcium inophore," Mol. Cell. Biol. 7(10):3490-3502 (1987).
Noda, et al., "Existence of distinct sodium channel messenger RNAs in rat brain," Nature 320:188-192 (1986).
Noda, et al., "Expression of functional sodium channels from cloned cDNA," Nature 322:826-828 (1986).
Mierendorf, et al., "Gene isolation by screening Kgtll libraries with antibodies," Methods in Enz. 152:458-469 (1986).
Gustin, et al., "Ion channels in yeast," Science 233:1195-1197 (1986).
Striessnig, et al., "Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel," FEBS Letters 212(2):247-253 (1987).
Froehner, "New insights into the molecular structure of the dihydropyridine-sensitive calcium channel," TINS 11(3):90-92 (1988).
Catterall, et al., "Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle," J. Biol. Chem. 263(8):3535-3538 (1988).
Curtis, et al., "Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules," Biochemistry 23(10):2113-2118 (1984).
Borsotto, et al., "The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca.sup.2+ channel," J. Biol. Chem. 260(26):14255-14263 (1985).
Cooper, et al., "Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue," J. Biol. Chem. 262(2):509-512 (1987).
Wood, "Gene cloning based on long oligonucleotide probes," Methods in Enzymology 152:443-447 (1987).
Schmid, et al., "Immunochemical analysis of subunit structure of 1,4-dihydropyridine receptors associated with voltage-dependent Ca.sup.2+ channels in skeletal, cardiac, and smooth muscles," Biochemistry 25:3492-3495 (1986).
Mishina, et al., "Location of functional regions of acetylcholine receptor .alpha.-subunit by site-directed mutagenesis," Nature 313:364-369 (1985).
Hamill, et al., "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches," Pfluger Archiv.European Journal of Physiology 391:85-100 (1981).
Hess, et al., "Different modes of Ca channel gating behavior favored by dihydropyridine Ca agonist and antagonists," Nature 311:538-544 (1984).
Leung, et al., "Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle," J. of Biol. Chem. 263(2):994-1001 (1988).
Imagawa, et al., "Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca.sup.2+ channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle," J. of Biol. Chem. 262(17):8333-8339 (1987).
Miller, "Multiple calcium channels and neuronal function," Science 235:46-52 (1987).
Kozak, "An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs," Nucleic Acids Research 15(20):8125-8148 (1987).
von Heijne, "Signal sequences: the limits of variation," Jour. of Mol. Biol. 184:99-105 (1985).
Hubbard, et al., "Synthesis and processing of asparagine-linked oligosaccharides.sup.1,2," Ann. Rev. Biochem. 50:555-583 (1981).
Feramisco, et al., "Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase," Journal of Biological Chemistry 255(9):4240-4245 (1980).
Takahashi, et al., "Identification of an .alpha. subunit of dihydropyridine-sensitive brain calcium channels," Science 236:88-91 (1987).
Hofmann, et al., "Regulation of the L-type calcium channel," TINS 8:393-398 (1987).
Curtis, et al., "Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules," Biochemistry 25:3077-3083 (1986).
Smith, et al., "Calcium channel activity in a purified dihydropyridine-receptor preparation of skeletal muscle," Biochemistry 26:7182-7188 (1987).
Meshi, et al., "Nucleotide sequence of the 30K protein cistron of cowpea strain of tobacco mosaic virus," Nucleic Acids Research 10(19):6111-6117 (1982).
Nikaido, et al., "Molecular cloning of cDNA encoding human interleukin-2 receptor," Nature 311:631-636 (1984).
Roberts, et al., "Paraneoplastic myasthenic syndrome IgG inhibits .sup.45 Ca.sup.2+ flux in a human small cell carcinoma line," Nature 317:737-739 (1985).
Starr, et al., "Primary structure of a calcium channel that is highly expressed in rat cerebellum," Proc. Natl. Acad. Sci. USA 88:5621-5625 (1991).
Snutch, et al., "Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS," Neuron 7:45-57 (1991).
Hui, et al., "Molecular cloning of multiple sybtypes of a novel rat brain isoform of the a.sub.1 subunit of the voltage-dependent calcium channel," Neuron 7:35-44 (1991).
Bean et al., "Classes of calcium channels in vertebrate cells," Annu. Rev. Physiol. 51:367-384 (1989).
Swandulla, et al., "Do calcium channel classifications account for neuronal calcium channel diversity?" TINS 14(2):46-51 (1991).
Ruth, et al., "Primary structure of the .alpha. subunit of the DHP-sensitive calcium channel from skeletal muscle," Science 245:1115-1118 (1989).
Mikami, et al., "Primary structure and functional expression of the cardiac

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