Assays, methods and means for modulating e2f activity

Details Assays, methods and means for modulating e2f activity Assays, methods and means for modulating e2f activity

2005-05-10

2005-05-10

Canella, Karen A. (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S006120, C435S007100

Reexamination Certificate

active

06890709

ABSTRACT:
P/CAF interacts with and acetylates E2F, this acetylation affecting ability of E2F to stimulate transcription. Interaction between P/CAF and E2F and acetylation of E2F by P/CAF are modulated, affecting ability of E2F to stimulate transcription, induction of S-phase in cells, oncogenicity of cells, and induction of apoptosis in cells. Agents are obtained for treatment of disorders of cell growth.

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