Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1981-08-20
1984-03-06
Marantz, Sidney
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436 86, 436172, 436536, 436546, 436800, G01N 3352, G01N 3354, G01N 3358, G01N 3368
Patent
active
044355092
ABSTRACT:
Process for carrying out an analytical determination of the presence of a substance by means of chemiluminescence, comprising employing fluorescein isothiocyanate (FITC) as a labelling agent, triggering a chemiluminescence reaction by adding an aqueous solution of sodium hypochlorite, and measuring the emission of light.
REFERENCES:
patent: 4104029 (1978-08-01), Maier
patent: 4238195 (1980-12-01), Boguslaski
Simpson et al, "A stable chemiluminesent-labelled antibody for immunological assay", Nature, vol. 279, Jun. 1979, pp. 646 and 647.
Erkki Soini et al, "Fluoroimmunoassay: Present Status and Key Problems", Clinical Chemistry, vol. 25, No. 3, 1979, pp. 353 to 361.
Robert Nilsson et al, "Role of Singlet Oxygen in Some Chemiluminescence and Enzyme Oxidation Reactions", The Journal of Physical Chemistry, vol. 78, No. 17, Aug. 15th, 1974, pp. 1681 to 1683.
J. L. Riggs et al, "Isothiocyanate Compounds as Fluorescent Labeling Agents for Immune Serum", Amer. I. Pathol., vol. 34, No. 6, pp. 1081 to 1092.
John D. Marshall et al, "Superiority of Fluorescein Isothiocyanate (Riggs) for Fluoroscent-Antibody . . . ", Proc. Soc. Experimental Biol. Med., vol. 98, 1958, pp. 898 to 900.
Fiorenzo Paronetto, "The Fluorescent Antibody . . . ", Proc. Soc. Experimental Biol. Med., vol. 113, 1963, pp. 394 to 397.
Pressman et al, The Structural Basis of Antibody Specificity, W. A. Benjamin, Inc., 1968, pp. 8 to 15, New York, 1968.
Berthold Fritz
Kubisiak Helmut
Laboratorium Prof. Dr. Rudolf Berthold
Marantz Sidney
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