Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1998-07-07
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 9121, 435 9151, 536 231, 536 2431, 536 2433, 935 3, 935 8, 935 78, C12Q 168, C07H 2104, C12P 1934
Patent
active
057766797
ABSTRACT:
Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
REFERENCES:
patent: 4737454 (1988-04-01), Dattagupta et al.
patent: 5270201 (1993-12-01), Richards et al.
Blackburn (1991), Structure and function of telomeres, Nature 350:569-573.
Blackburn (1991), Telomerases, Ann. Rev. Biochem. 61:113-129.
Blackburn et al. (1989), Recognition and elongation of telomeres by telomerase, Genome 31:553-560.
Counter et al. (1992), Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity, EMBO J. 11(5): 1921-1929.
Czech (25 Nov. 1988), Ribozymes and their medical implications, JAMA 260(20):3030-3034.
Eck and Nabel (1991), Antisense oligonucleotides for therapeutic intervention, Current Opinions Biotechnology 2:897-9904.
Greider (Sep. 1991), Telomerase is processive, Mol. Cell. Bio. 11:4572-4580.
Greider and Blackburn (24 Dec. 1987), The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity, Cell 51:887-898.
Greider and Blackburn (26 Jan. 1989), A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis, Nature 337(6205):331-337.
Harley et al. (31 May 1990), Telomeres shorten during ageing of human fibroblasts, Nature 345:458-460.
Harley et al. (1991), Telomere loss: Mitotic clock or genetic time bomb? Mut. Res. 256:271-282.
Morin (3 Nov. 1989), The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG Repeats, Cell, 59:521-529.
Morin (8 Oct. 1991), Recognition of a chromosome truncation site associated with alpha-thalassaemia by human telomerase, Nature 353:454-456.
Romero and Blackburn (18 Oct. 1991), A conserved econdary structure for telomerase RNA, Cell 67:343-353.
Shippen-Lentz and Blackburn (2 Feb. 1990), Functional evidence for an RNA template in telomerase, Science 247:546-552.
Yu et al. (8 Mar. 1990), In vitro alteration of telomere sequences and sequences caused by mutated Tetrahymena telomerase RNAs, Nature 344:126-132.
Yu and Blackburn (15 Nov. 1991), Developmentally programmed healing of chromosomes by telomerase in Tetrahymena, Cell 67:823-832.
Zahler et al. (25 Apr. 1991), Inhibition of telomerase by G-Quarter DNA tructures, Nature 350:718-720.
Lingner et al. (1984), Telomerase RNAs of different ciliates have a common secondary structure and a permuted template, Genes and Development 8:1989-1998.
Singer and Gottschling (1994), TLC1: Template RNA Component of Saccharomyces cerevisiae Telomerase, Science 266:404-409.
Kim et al. (1994), Specific association of Human Telomerase Activity with Immortal Cells and Cancer, Science 266:2011-2014.
Blackburn, E.H., "Telomers," TIBS, 16:378:381 (1991).
Blackburn, E.H., Grant Abstracts 5R01 GM 32565-11; 5P30 ES01896-15UB; 5R37 GM26259-16.
Counter et al., "Telomerase activity in human ovarian carcinoma,"PNAS, 91:2900-2904 (1994).
Feng, J. et al., "The RNA Component of Human Telomerase," Science, 269:1236-1241.
Greider, C.W., Cold Spring Harbor Symposia on Quantitative Biology, vol. LVIII, Cold Spring Harbor Laboratory, New York (1993).
Grieder, C.W., Grant Abstracts 5RO1 RG09383; 5RO1 GM43080-04.
Nilsson, P. et al., "Telomerase activity in vivo in human malignant hematopoietic cells,"Oncogene, 9:3043-3048 (1994).
Prowse et al., Proc. Nat. Acad. Sci. USA, 90:1493- (1993).
Rennie, J., "Immortal's Enzyme," Scientifc American, Jul. 1994, pp. 14-16 (1994).
Rensberger, B. "Cancer's Immortality May Depend on Enzyme," Washington Post, Apr. 12, 1994, pp. A1, A12.
Yan et al., J. Biol. Chem., 267:23226-23231 (1992).
Andrews William H.
Feng Junli
Funk Walter
Villeponteau Bryant
Geron Corporation
Kaster Kevin R.
Myers Carla J.
Storella John R.
LandOfFree
Assays for the DNA component of human telomerase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assays for the DNA component of human telomerase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assays for the DNA component of human telomerase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1204012