Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-03-29
2005-03-29
Harris, Alana M. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007400, C435S007500, C435S007920, C435S283100, C435S287100, C436S086000, C436S164000, C436S166000, C436S172000, C530S350000, C530S386000, C530S387100
Reexamination Certificate
active
06872537
ABSTRACT:
This invention provides methods for the screening and identification of agents having potent effects on the progression of the cell cycle. In one embodiment, the methods involve contacting a polymerized microtubule with a microtubule severing protein or a microtubule depolymerizing protein in the presence of an ATP or a GTP and a test agent; and (ii) detecting the formation of tubulin monomers, dimers or oligomers. The p60 subunit of katanin provides a particularly preferred microtubule severing protein possessing both ATPase and microtubule severing activities.
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Hartman James J.
Vale Ronald D.
Harris Alana M.
Medlen & Carroll LLP
Regents of the University of California
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