Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2000-10-13
2010-02-16
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S024300, C536S025320, C536S026600
Reexamination Certificate
active
07662550
ABSTRACT:
The invention provides assays that can detect multiple genetic variants of a gene (e.g., a mycobacterial gene) in a sample using a pool (e.g., 2, 3, 4, or more) of oligonucleotide hybridization probes.
REFERENCES:
patent: 5210015 (1993-05-01), Gelfand et al.
patent: 5328825 (1994-07-01), Warren et al.
patent: 5487972 (1996-01-01), Gelfand et al.
patent: 5925517 (1999-07-01), Tyagi et al.
patent: 6103476 (2000-08-01), Tyagi et al.
patent: 6461817 (2002-10-01), Alland et al.
patent: WO 99/40226 (1999-08-01), None
Kostrikis et al., “Spectral Genotyping of Human Alleles”,Science, vol. 279, pp. 1228-1229 (Feb. 20, 1998).
Piatek et al., “Molecular beacon sequence analysis for detecting drug resistance inMycobacterium tuberculosis”, Nature Biotechnology, vol. 16, pp. 359-363 (Apr. 1998).
Tyagi et al., “Molecular Beacons: Probes that Fluoresce upon Hybridization”,Nature Biotechnology, vol. 14, No. 3, pp. 303-308 (Mar. 1996).
Marras et al., “Multiplex detection of single-nucleotide variations using molecular beacons”, Genetic Analysis: Biomolecular Engineering, vol. 14, pp. 151-156 (1999).
Piatek et al., “Molecular beacon sequence analysis for detecting drug resistance inMycobacterium tuberculosis”, Nature Biotechnology, vol. 16, pp. 359-363 (Apr. 1998).
Vet et al., “Multiplex detection of four pathogenic retroviruses using molecular beacons”, Proc. Natl. Acad. Sci. USA, vol. 96, pp. 6394-6399 (May 1999).
Tyagi, S. et al. “Multicolor molecular beacons for allele discrimination” Nature Biotechnology (1998) 16: 49-53.
Alland David
Kramer Fred R.
Tyagi Sanjay
Fox Rothschild LLP
Horlick Kenneth R.
Norton Gerard P.
PHRI Properties, Inc.
Tung Joyce
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