Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-11-29
2010-11-23
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007910, C435S007920
Reexamination Certificate
active
07838249
ABSTRACT:
Methods of determining intracellular levels of Rab5 activity are disclosed, as well as fusion proteins utilized in such methods and recombinant constructs encoding such fusion proteins. The fusion protein contains a Rab5-binding domain that specifically binds to an activated form of Rab5-GTP, and a tag conjugated thereto, wherein the tag binds to an affinity matrix for purification of Rab5-GTP. Also disclosed are kits for determining intracellular levels of Rab5 activity.
REFERENCES:
patent: 2005/0014206 (2005-01-01), Vodermaier et al.
Stetnmark et al. (Cell 1995, vol. 83, p. 423-432).
Colman et al in Research in Immunology (145(1):33-36, 1994.
Abaza et al in Journal of Protein Chemistry (11(5):433-444, 1992).
Lederman et al in Molecular Immunology (28:1171-1181, 1991).
Cheu Jacob
Dunlap Codding P.C.
The Board of Regents of the University of Oklahoma
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