Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-06-02
2008-10-07
Haddad, Maher M. (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S810000, C530S300000
Reexamination Certificate
active
07432061
ABSTRACT:
Methods for determining matrix metalloproteinase (MMP) activity in biological samples are described. The methods of the invention are useful to assess disease severity or progression, diagnose a particular disease, or develop a profile of MMP activity for inflammatory diseases such as arthritis, or cancer. The methods of the invention involve the use of particular amino acid sequences in substrates to measure the activity in biological samples of MMP's including collagenase 3, stromelysin 1, gelatinase A, gelatinase B and collagenase 1. A diagnostic kit for use in determining the amounts of MMP activities in biological samples is also provided.
REFERENCES:
patent: 6030792 (2000-02-01), Otterness et al.
patent: 6127139 (2000-10-01), Te Koppele et al.
patent: 2002/0061569 (2002-05-01), Haselbeck et al.
patent: 2003/0087863 (2003-05-01), Martignetti et al.
patent: 2003/0180877 (2003-09-01), Deleersnijder et al.
patent: WO 01/81581 (2001-04-01), None
patent: WO 02/051444 (2002-07-01), None
GenBank Accession No. A54808, May 7, 1999.
GenBank Accession No. E64716, Sep. 29, 1999.
GenBank Accession No. B71803, Sep. 29, 1999.
Attwood et al. The Babel of Bioinformatics. Science. 290:471-473.
Skolnik et al. ‘From genes to protein structure and fucntion: novel applications of computational approaches in the genomic era.’ Trends in Biotech. 18:34-39, 2000.
Beekman B. et al., Highly Increased Levels of Active Stromelysin in Rheumatoid Synovial Fluid Determined by a Selective Fluorogenic Assay (1997),FEBS Letters418: 305-309.
Beekman B. et al., Fluorogenic MMP Activity Assay for Plasma Including MMPs Complexed to α2-Macroglobulin (1999),Annals N.Y. Acad. of Sci. 878: 150-158.
Beekman B., et al., Convenient Fluorometric Assay for Matrix Mettaloproteinase Activity and its Application in Biological Media, (1996),FEBS Letters390: 221-225.
Bode W., et al. The Metzincin-Superfamily of Zinc-Peptidases (1996),Intraellular Protein Catabolism1-11, Suzuki and Bond (eds.), Plenum Press, NY.
Deng S., et al., Substrate Specificity of Human Collagenase 3 Assessed Using a Phage-Displayed Peptide Library (2000),Jour. Biol. Chem. 275(40): 31422-31427.
Chen, et al. A Unique Substrate Recognition Profile for Matrix Mettalloproteinase-2*, (2002)Jour. Biol. Chem., 277(6): 4485-4491.
Clark Billinghurst R., et al., Enhanced Cleavage of Type II Collagen by Collagenases in Osteoarthritic Articular Cartilage (1997),J. Clin.. Invest. 99(7): 1534-1545.
Dahlberg, L. et al., Selective Enhancement of Collagenase-Mediated Cleavage of Resident Type II Collagen in Cultured Osteoarthritic Cartilage and Arrest With a Synthetic Inhibitor That Spares Collagenase 1 (Matrix Metalloproteinase 1) (2000),Arthritis Rheum., 43(3): 673-682.
Elliott, S, et al. ,The Clinical Potential of Matrix Metalloproteinase Inhibitors in The Rheumatic Disorders (2001),Drugs and Aging18(2): 87-99.
Hanemaauer, et al., MMP-9 Activity in Urine From Patients With Various Tumors, as Measured by a Novel MMP Activity Assay Using Modified Urokinase as a Substrate (1999) .Annals N.Y. Acad. of Sci. 878: 141-149.
Huebner, et al., Collagenase 1 and Collagenase 3 Expression in a Guinea Pig Model of Osteoarthritis (1998),Arthritis Rheum, 41(5): 877-890.
Kridel S. et al., Substrate Hydrolysis by Matrix Metalloproteinase-9* (2001),Jour. Biol. Chem., 276(23): 20572-20578.
Manicourt D-H et al., Serum Levels of Collagenase, Stromelysin-1, and TIMP-1 (1994)Arthritis&Rheumatism,37(12):: 1774-1783.
Mohtai M. et al., Expression of 92-kD Type IV Collagenase/Gelatinase (Gelatinase B) in Osteoarthritic Cartilage and its Induction in Normal Human Articular Cartilage by Interleukin 1 (1993),J. Clin. Invest., 92: 179-185.
Naito K. et al. Measurement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) in Patients With Knee Osteoarthritis: Comparison With Generalized Osteoarthritis (1999),Rheumatology 38:510-515.
Saltarelli M. et al ,Measurement of Unitary Type II Collagen Neoepitope (uTIINE) Levels in Rheumatoid Arthritis (RA) Patients to Assess Joint Status (1999),Arthritis Rheum, 42(9): S249.
Smith M. et al., Rapid Identification of Highly Active and Selective Substrates for Stromelysin and Matrilysin Using Bacteriophage Peptide Display Libraries* (1995),Jour. Biol. Chem., 270(12): 6440-6449.
Sopata I. et al. Neutrophil Gelatinase Levels in Plasma and Synovial Fluid of Patients With Rheumatic Diseases (1995),Rheumatol Int., 15:9-14.
Stamenkovic, I. Matrix Metalloproteinases in Tumor Invasion and Metastasis (2000),Cancer Biology, 10: 415-433.
Takei I. et al., Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Joint Fluid of the Patients With Loose Artificial Hip Joints (1999) , J. Biomed. Mater. Res. 45(3): 175-183.
Woodworth T. Urinary Type II Collagen Neoepitope (uTIINE) in Osteoarthritis (OA) Patients is Associated With Disease Severity (1999),Arthritis and Rheumatism, 42(9): S258.
Verheijen J. et al., Modified Proenzymes as Artificial Substrates for Proteolytic Enzymes: Colorimetric Assay of Bacterial Collagenase and Matrix Metalloproteinase Activity Using Modified Pro-Urokinase (1997),Biochem. J., 323: 606-609.
Walakovits, L. et al., Detection of Stromelysin and Collagenase in Synovial Fluid From Patients With Rheumatoid Arthritis and Posttraumatic Knee Injury (1992),Arthritis&Rheumatism, 35(1): 35-42.
Yoshihara Y. et al., Increased Levels of Stromelysin-1 and Tissue Inhibitor of Metalloproteinases-1 in Sera From Patients With Rheumatoid Arthritis (1995),Arthritis&Rheumatism, 38(7): 969-975.
Zucker, S. et al., Critical Appraisal of the Use of Matrix Metalloproteinase Inhibitors in Cancer Treatment (2000) ,Oncogene, 19(56): 6642-6650.
Moss Marcia Lynn
Rasmussen Fred H.
Vitek Michael P.
BioZyme, Inc.
Haddad Maher M.
Kiefer Laura L.
Rooney Nora M
LandOfFree
Assays for measuring matrix metalloproteinase activities does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assays for measuring matrix metalloproteinase activities, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assays for measuring matrix metalloproteinase activities will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4004448