Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-11-15
1998-09-01
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 231, 536 235, 514 44, 800 2, C12Q 168
Patent
active
058009981
ABSTRACT:
Assays for determining whether a subject has or is at risk for developing type II diabetes, which are based on detecting the presence or absence of alterations in the hepatic nuclear factor 1 (HNF-1) gene or protein of the subject are disclosed.
REFERENCES:
Byrne, Maria M. et al. (1996) "Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects with Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12" Diabetes 45:1503-1510.
Fajans, Stefan S. et al. (1994), "Maturity-Onset Diabetes of the Young", Life Sciences, 6(55):413-422.
Vaxillaire, Martine et al. (1995) "A Gene for Maturity Onset Diabetes of the Young (MODY) Maps to Chromosome 12q", Natural Genetics 9: 418-423.
Zhong, Weimin et al. (1994) "Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression", Molecular and Cellular Biology 11(14):7276-7284.
Barrera-Hernandez, Gonzalo et al. (1996) "Effects of Diabetes Mellitus on Hepatocyte Nuclear Factor 1 Decrease Albumin Gene Transcription", The Journal of Biological Chemistry 17(271):9969-9975.
Bach, Ingolf and Yaniv, Moshe (1993) "More Potent Transcriptional Activators or a Transdominant inhibitor of the HNF1 Homeoprotein Family are Generated by Alternative RNA Processing", The IMBO Journal 11(12):4229-4242 (and corrigendum).
Ringeisen, Fran.cedilla.ois et al. (1992) "The Transactivation Potential of Variant Hepatocyte Nuclear Factor 1 is Modified by Alternative Splicing", The Journal of Biological Chemistry 34(268):25706-25711.
Stoffel, Markus et al. (1996) "A Yeast Artificial Chromosome-Based Map of the Region of Chromosome 20 Containing the Diabetes-Susceptibility Gene, MODY1, and a Myeloid Leukemia Related Gene", Proc. Natl. Acad. Sci., USA 93:3937-3941.
Byrne, Maria M. et al. (1995) "Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20" Diabetes 44:699-704.
Vaxillaire, Martine et al., (1994) "Search for a Third Susceptibility Gene for Maturity-Onset Diabetes of the Young" Diabetes 43:389-393.
Drewes, Thorsten et al., (1996) "Human Hepatocyte Nuclear Factor 4 Isoforms are Encoded by Distinct and Differently Expressed Genes" Molecular and Cellular Biology 3(16):925-931.
Beck-Nielsen, Henning et al., (1988) "Insulin Action and Insulin Secretion in Identical Twins with MODY" Diabetes 37:730-735.
Lesage, Suzanne et al., (1995) Linkage Analyses of the MODY3 Locus on Chromosome 12q with Late-Onset NIDDM, Diabetes 44:1243-1247.
Webster's II New Riverside University Dictionary. The Riverside Publishing Company, p. 687, 1994.
Arnold, Esq. Beth E.
Chambers Jasemine C.
Clark Deborah J. R.
Millennium Pharmaceuticals Inc.
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