Assays for cartilage synthesis in osteoarthritis based on detect

Details Assays for cartilage synthesis in osteoarthritis based on detect Assays for cartilage synthesis in osteoarthritis based on detect

1996-07-17

1998-07-14

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 792, G01N 3353, G01N 33567

Patent

active

057802408

ABSTRACT:
Assays for determining cartilage synthesis associated with osteoarthritis are presented. The assays are based on detection of type IIA procollagen or propeptide, or type IIA mRNA in a tissue or fluid sample from a non-neonatal individual being tested. Since type IIA procollagen is not found in normal non-neonatal individuals, type IIA procollagen and the mRNA which encodes it are unique markers for osteoarthritis which exhibits neonatal like cartilage synthesis as part of the disease syndrome.

REFERENCES:
Ryan et al., J. Biol. Chem. 265:10334, 1990.
Shinmei et al., Osteoarthritis and Cartilage 1:128, 1993.

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