Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-02-18
1996-07-30
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
935 77, 935 78, C12Q 168
Patent
active
055410669
ABSTRACT:
Assays for determining cartilage synthesis associated with osteoarthritis are presented. The assays are based on detection of collagen type IIA procollagen or propeptide, or collagen type IIA mRNA in a tissue or fluid sample from a non-neonatal individual being tested. Since type II A procollagen is not found in normal non-neonatal individuals, type IIA procollagen and the mRNA which encodes it are unique markers for osteoarthritis which exhibits neonatal like cartilage synthesis as part of the disease syndrome.
REFERENCES:
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Meyer Virginia H.
Zitomer Stephanie W.
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