Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1991-08-15
1995-07-04
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 691, 4352402, 435 72, C12Q 102
Patent
active
054299217
ABSTRACT:
Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
REFERENCES:
patent: 4788135 (1988-11-01), Davis et al.
patent: 4912202 (1990-03-01), Campbell et al.
patent: 4954436 (1990-09-01), Froehner et al.
patent: 5024939 (1991-06-01), Gorman
Pragnell, et al., "Cloning and tissue-specific expression of the brain calcium channel .beta.-subunit," FEBS Letters, 291:253 (1991).
DeJongh, et al., "Subunits of purified calcium channels, " J. Biol. Chem., 265 (25): 14738-14741 (1990). (Best available copy, sufficiently leigible for applicant to read).
Carbone, et al., "Ca currents in human neuroblastoma IMR32 cells: kinets, permeability and pharmacology," Pfluegers Arch. 416:170-179 (1990). (Best available copy, sufficiently legible for applicant to read).
Bosse, et al., "The cDNA and deduced amino acid sequence of the .gamma.subunit of the L-type calcium channel from rabbit skeletal muscle," FEBS 267 (1) 153-156 (1990).
Burns, et al., "Calcium channel activity of purified human synexin and structure of the human synexin gene," P.N.A.S. 86:3798-3802 (1989).
Campbell, et al., "32,000-Dalton subunit of the 1,4-dihydropyridine receptor," Ann. N.Y. Acad. Sci. 560:251-257 (1989).
Dascal, N., "The use of Xenopus oocytes for the study of ion channels," CRC Critical Rev. Biochem. 22 (4): 317-387 (1987).
De Jongh, et al., "Subunits of purified calcium channels," J. Bio. Chem. 265 (25)14738-14741 (1990).
Jay, et al., "Primary structure of the .gamma. subunit of the DHP-sensitive calcium channel from skeletal muscle," Science 248: 490-492 (1990).
Jay et al., "Structural characterization of the dihydropyridine-sensitive calcium channel .alpha.hd 2-subunit and the associated .delta. peptides," J. Bio. Chem. 266 (5) 3287-3293 (1991).
Leung, et al., "Monoclonal antibody characterization of the 1, 4-dihydrophyridine receptor of rabbit skeletal muscle," Ann. N.Y. Acad. Sci. 522: 43-46 (1988).
Starr, et al., "Primary structure of a calcium channel that is highly expressed in the rat cerebellum," P.N.A.S. 88: 5621-5625 (1991).
Vaghy, et al., "Mechanism of Action of Calcium Channel Modulator Drugs," Ann. N.Y. Acad. Sci. 522: 176-186 (1988).
Ahlijanian et al., "Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina," Neuron, 4: 819-832 (1990).
Blount et al., "Assembly Intermediates of the Mouse Muscle Nicotinic Acetylcholine Receptor in Stably Transfected Fibroblasts," J. Cell. Biol., 111: 2601 (1990).
Carbone et al., "Ca currents in human neuroblastoma IMR32 cells: kinetics, permeability and pharmacology," Pfugers Arch., 416: 170-179 (1990).
Dascal et al., "Expression of modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes," Science, 231: 1147-1150 (1986).
Hess et al., "Calcium channels in vertebrate cells," Ann. Rev. Neurosci., 13: 337-356 (1990).
Stanley et al., "Characterization of a Calcium Current in a Vertebrate Cholinergic Presynaptic Nerve Terminal," J. Neurosci., 11:985 (1991).
Wei, et al., "Heterologous regulation of the cardiac Ca.sup.2+ channel .alpha..sub.1 subunit by skeletal muscle .beta. and .gamma. subunits," J. Biol. Chem. 266: 21943-21947 (1991).
Koch, et al., "cDNA Cloning of a Dihydropyridine-sensitive Calcium Channel from Rat Aorta," J. Bio. Chem. 265 (29): 17786-17791 (1990).
Sher, et al., ".omega.-Conotoxin binding and effects on calcium channel function in human neuroblastoma and rat pheochromocytoma cell lines," FEBS 235 (1, 2):178-182 (1988).
Sher, et al., "Voltage-operated Calcium Channels in Small Cell Lung Carcinoma Cell Lines: Pharmacological, Functional, and Immunological Properties," Cancer Res. 50 (13): 3892-3896 (1990).
Powers et al. (1991) Assignment of the Human Gene for the .alpha..sub.1 Subunit of the Cardiac DHP-Sensitive Ca.sup.2+ Channel (CCHL1A1) to Chromosome 12p12-pter Genomics 10: 835-839.
Kim et al., "IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels," Science, 239: 405-409 (1988).
Claudio et al., "Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts," Science, 238: 1688-1694 (1987).
Tanabe et al., "Primary structure of the receptor for calcium channel blockers from skeletal muscle," Nature, 328: 313-318 (1987).
Nakayama et al., "Purification of a putative Ca.sup.2+ channel protein from rabbit skeletal muscle," J. Biol. Chem., 262: 6572-6576 (1987).
Vaghy et al., "Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparation," J. Biol. Chem., 262 (29): 14337-14342 (1987).
Leung et al., "Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca.sup.2+ channel from rabbit skeletal muscle," J. Biol. Chem., 262 (17): 7943-7946 (1987).
Sharp et al., "Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor," J. Biol. Chem., 62 (25): 12309-12315 (1987).
Takahashi et al., "Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle," Proc. Natl. Acad. Sci (USA), 84:5478-5482 (1987).
Takahashi and Catterall, "Dihydropyridine-sensitive calcium channels in cardiac and skeletal muscle membranes: studies with antibodies against the .alpha.-subunits," Biochemistry, 26 (17): 5518-5526 (1987).
Morton and Froehner, "Monoclonal antibody identifies a 200-kDA subunit of the dihydropyridine-sensitive calcium channel," J. Biol. Chem., 262 (25): 11904-11907 (1987).
Barhanin et al., "The calcium channel antagonists receptor from rabbit skeletal muscle: reconstitution after purification and subunit characterization," Eur. J. Biochem., 164: 525-531 (1987).
Sieber et al., "The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel," Eur. J. Biochem., 167: 117-122 (1987).
Lang et al., "The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse," J. Physiol., 390:257-270 (1987).
Curran and Morgan, "Barium modules c-fos expression and post-translational modification," Proc. Natl. Acad. Sci., 83: 3521-8524 (1986).
Fisch et al., "c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-0-tetradecanoyl phorbol-13-acetate, and the calcium ionophore," Mol. Cell. Biol., 7 (10): 3490-3502 (1987).
Noda et al., "Existence of distinct sodium channel messenger RNAs in rat brain," Nature, 320: 188 -192 (1986).
Noda et al., "Expression of functional sodium channels from cloned cDNA," Nature, 322: 826-828 (1986).
Mierendorf et al., "Gene isolation by screening kgtll libraries with antiboides," Methods in Enz., 152: 458-469 (1986).
Gustin et al., "Ion channels in yeast," Science, 233: 1195-1197 (1986).
Striessnig et al., "Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel," FEBS Letters, 212: (2) 247-253 (1987).
Froehner, "New insights into the molecular structure of the dihydropyridine-sensitive calcium channel,": TINS, 11 (3): 90-92 (1988).
Catterall et al., "Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle," J. Bio. Chem., 263 (8): 3535-3538 (1988).
Curtis et al., "Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules," Biochemistry, 23 (10): 2113-2118 (1984).
Borsotto et al., "The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca.sup.2+ channel," J. Biol. Chem., 260 (26): 14255-14263 (1985).
Cooper et al., "Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue," J. Biol. Chem., 262 (2): 509-512 (1987).
Wood, "Gene cloning based on long oligonucleotide probes," Methods in Enzymology, 152: 443-447 (1987).
Schmid et al., "Immunochemical analysis of subunit structure of 1, 4-dihydropyridine receptors associated with voltage-dependent Ca.sup.
Brenner Robert
Ellis Steven B.
Feldman Daniel H.
Harpold Michael M.
McCue Ann F.
Draper Garnette D.
Fitzgerald David L.
The Salk Institute Biotechnology/Industrial Assoc. Inc.
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