Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Reexamination Certificate
2007-06-19
2007-06-19
Weber, Jon (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
C435S007720
Reexamination Certificate
active
11180206
ABSTRACT:
Methods and compositions for measuring N-dealkylating activity of cytochromes P450 enyzmes are disclosed.
REFERENCES:
patent: 6130342 (2000-10-01), Miller et al.
Bellec et al.Cytochrome P450 Metabolic Dealkylation of Nine N-nitrosodialkylamines by Human Liver Microsomes; Carcinogenesis, vol. 17, No. 9 (1996) pp. 2029-2034.
Moller et al. 9-aminoacridine as a Fluorescent Probe of the Electrical Diffuse Layer Associated With the Membranes of Plant Mitochondria; Biochem. J., vol. 193 (1981) pp. 37-46.
Stresser et al. Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYPD2D2 and Human CYP3A4; Drug Metabolism and Disposition, vol. 30, No. 7 (2002) pp. 845-852.
Carratore et al. Cloning and Expression of Rat CYP2E1 inSaccharomyces cervisiae:Detection of Genotoxicityof N-Alkylformamides; Environmental and Molecular Mutagenesis, vol. 36 (2000) pp. 97-104.
Galy et al. Preparation of a Series of 9-Alkylaminoacridines and 9-Imino-10-Alkylacridines and Their Binding to Desoribonucleic Acid; Arzneimittel-Forschung, vol. 37, No. 10 (1987) pp. 1095-1098.
Spatzenegger, M. et al., Clinical Importance of hepatic cytochrome P450 in drug metabolism, Drug Metab Rev., 27(3): 397-417 (1995).
Murray, Michael, P450 Enzymes Inhibition Mechanisms. Genetic Regulation and Effects of Liver Disease, Clin. Pharmacokinet, 23(2): 132-146 (1992).
Niwa, T. et al., Contribution of human hepatic cytochrome P450s and steroiodgenic CYP17 to the N-demethylation of aminopyrine, 29(2): 187-93 (1999) [Abstract only].
Chiron, Julien et al., Reactivity of the Acridine Ring: A Review, Synthesis, pp. 313-325 (2004) [Abstract only].
Crespi, Charles L. et al., Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450, Anal. Biochem., 248: 188-190 (1997).
Doostdar, Hamed et al., Bioflavonoids: selective substrates and Inhibitors for cytochrome P450 CYP1A and CYP1B1, Toxicology, 144: 31-38 (2000).
Moody, G.C. et al., Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) . . . , Xenobiotica, 29(1): 53-75 (1999) [Abstract only].
Stresser, David M et al., Highly Selective Inhibition of Human CYP3A In Vitro by Azamulin and Evidence . . . , Drug Metabolism and Disposition, 32: 105-112 (2004).
Kupfer, David et al., Determination of Enzymic Demethylation of p-Chloro-N-methylaniline.., Anal. Biochem., 17: 502-512 (1966).
Netter, K.J., Naunyn Schmiedebergs Arch Pharmakol Exp Pathol, 255 (2): 151-62 (1966) [Abstract only].
Van der Hoeven, Th., A Sensitive, Fluorometric Method for the Assay of Microsomal Hydroxylase: N-Demethylation . . . , Anal. Biochem., 77: 523-528 (1977).
Yamamoto, T. et al., High-throughput screeening to estimate single or multiple enzymes nlvolved in drug metabolism . . . , Xenobiotioa, 33(8): 823-39 (2003 [Abstract only].
Dolence E. Kurt
Mayer Gabriele E.
Mayer Richard T.
Dann Dorfman Herrell and Skillman, P.C.
Hagan, Esq. Patrick J.
Martin Paul
The United States of America as represented by the Secretary of
The University of Wyoming
LandOfFree
Assays employing novel substrates for measuring... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assays employing novel substrates for measuring..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assays employing novel substrates for measuring... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3888139