Assays and methods for determining STIM2 activity

Details Assays and methods for determining STIM2 activity Assays and methods for determining STIM2 activity

2011-06-14

2011-06-14

Prouty, Rebecca E (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S029000

Reexamination Certificate

active

07960129

ABSTRACT:
The present invention provides assays and methods for determining levels of STIM2 activity, thus providing tools for the characterization and study of the regulation of intracellular calcium levels.

REFERENCES:
patent: WO 2004/078995 (2004-09-01), None
Soboloff et al. ORAI1 and STIM2 Reconstitute Store-Operated Calcium Channel Function; The Journal of Biological Chemistry, vol. 281, No. 30 (2006) pp. 20661-20665.
Soboloff et al. STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Calcium Entry; Current Biology, vol. 16 (2006) pp. 1465-1470.
Hermosura et al. Dissociation of the Store-Operated Calcium Current ICRAC and the MG-Nucleotide-Regulated Metal Ion Current Magnum; Journal of Physiology, vol. 539.2 (2002) pp. 445-458.
Mathes et al. Calcium Release-Activated Calcium Current (ICRAC) Is a Direct Target for Sphingosine; The Journal of Biological Chemistry, vol. 273, No. 39 (1998) pp. 25020-25030.
Parvez et al. STIM2 Protein Mediates Distinct Store-Dependent and Store-Independent Modes of CRAC Channel Activation; The FASEB Journal, vol. 22 (2008) pp. 752-761.
Prakriya et al. Potentiation and Inhibition of CA2+ Release-Activated CA2+ Channels by 2-Aminoethyldiphenyl Borate (2-APB) Occurs Independently of IP3 Receptors; Journal of Physiology, vol. 536, No. 1 (2001) pp. 3-19.
Palade, P., “Drug-Induced Calcium Release from Isolated Sarcoplasmic Reticulum III. Block of Calcium-Induced Calcium Release by Organic Plyamines,” J. of Biological Chemistry, v. 262, n. 13, p. 6149-6154, (1987).
Ruano, Yolanda et al., Identification of Novel Candidate Target Genes in Amplicons of Glioblastoma Multiforme Tumors Detected by Expression and CGH Microarray Profiling. Molecular Cancer, Biomed Central, v. 5, n. 1, p. 39, Sep. 26, 2006.
Soboloff, Jonathan, et al., “Orai1 and STIM Reconstitute Store-Operated Calcium Channel Function,” J. of Biological Chemistry, v. 281, n. 30, p. 20661-20665, Jul. 30, 2006.
Soboloff, Jonathan, et al., “STIM2 is an Inhibitor of STIM1-Mediated Store-Operated Ca<2+> Entry,” Current Biology, Current Science, v. 16, n. 14, p. 1465-1470, Jul. 25, 2006.

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