Assays and devices for distinguishing between normal and abnorma

Details Assays and devices for distinguishing between normal and abnorma Assays and devices for distinguishing between normal and abnorma

1995-04-28

1998-07-28

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 5, 435 732, 435 792, 436161, G01N 33543

Patent

active

057862206

ABSTRACT:
Methods and devices for distinguishing between normal and abnormal pregnancies are provided. The methods rely on determining the concentration of progesterone or progesterone metabolite in a patient sample, where a concentration above a threshold value is indicative of a normal pregnancy. Preferably, the concentration of hCG is determined simultaneously, where an hCG concentration above a threshold value provides confirmation that the individual being tested is pregnant. An exemplary test device comprises a lateral flow membrane having zones for capturing label in response to the progesterone and hCG concentrations, respectively. Visible label is accumulated when the hCG concentration exceeds the threshold value but is absent when the progesterone concentration exceeds the threshold value.

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