Assaying method for primary amines using aromatic dialdehydes

Chemistry: analytical and immunological testing – Nitrogen containing – Amine and quaternary ammonium

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

204 1T, 436 86, 436 89, 436109, 436150, 436161, 436172, G01N 2177, G01N 2726, G01N 3368

Patent

active

048371661

ABSTRACT:
A method of assaying primary amines or cyanide is disclosed. The process is carried out by reacting a substituted or unsubstituted naphthalene-2,3-dicarboxaldehyde or o-phthalaldehyde, reactive with primary amines and cyanide, with cyanide ions and at least one primary amine to form an adduct amenable to fluorometric or electrochemical assaying techniques. The adduct is then fluorometrically or electrochemically assayed.
Also disclosed are 1-cyano-benz[f]isoindole adducts.

REFERENCES:
patent: 3718432 (1973-02-01), Roth
patent: 3892530 (1975-07-01), Felix et al.
patent: 3933430 (1976-01-01), Hare
patent: 4359323 (1982-11-01), LePage
patent: 4501816 (1985-02-01), Molla
patent: 4670403 (1987-06-01), Ishida et al.
Kobayashi et al., Anal. Biochem., vol. 112, pp. 99-104, 1981.
Honda et al., J. of Chromatography, vol. 303, pp. 173-176, 1984.
Miura et al., Chemical Abstracts, vol. 96, Abstract No. 96:65120r, 1981.
Ishida et al., J. of Chromatography, vol. 204, pp. 143-148, 1981.
Gardner et al., Anal. Biochem., vol. 101, pp. 61-65, 1980.
Allison et al., Anal. Chem., vol. 56, pp. 1089-1096, 1984.
Miura et al., Anal. Biochem., vol. 139, pp. 432-437, 1984.
Chemical Abstracts, 20064F, vol. 101, (1984), Miura et al.
Reaction of o-Phthalaldehyde with Alanine and Thiols: Kinetics and Mechanism Osborne S. Wong, 1985 American Chemical Society, vol. 107, p. 6421 of J. Am. Chem. Soc.
de Montigny et al "Naphthalene-2,3-dicarboxaldehyde/Cyanaide Ion: A Rationally Designed Fluorogenic Reagent for Primary Amines," Reprinted from Analytical Chemistry, vol. 59, p. 1096, Apr. 15, 1987.
Matuszewski et al. "N-Substituted 1-Cyanobenz[f]isoindole: Evaluation of Fluorescence Efficiencies of a New Fluorogenic Label for Primary Amines and Amino Acids", Reprinted from Analytical Chemistry, vol. 59, p. 1102, Apr. 15, 1987.
Carlson et al, "New Derivatizing Agents for Amino Acids and Peptides. 1. Facile Synthesis of N-Substituted 1-Cyanobenz[f]isoindoles and Their Spectroscopic Properties", Reprinted from the Journal of Organic Chemistry, 1986, 51,3978.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Assaying method for primary amines using aromatic dialdehydes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Assaying method for primary amines using aromatic dialdehydes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assaying method for primary amines using aromatic dialdehydes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-40374

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.