Assay to screen for anti-malarials

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007500, C435S007800, C435S007930, C435S007950, C435S287900, C435S947000, C436S503000, C436S518000, C436S524000, C436S527000, C436S086000, C436S172000, C436S175000, C436S177000, C530S822000, C530S350000

Reexamination Certificate

active

07611853

ABSTRACT:
Malarial parasitePlasmodium falciparumis responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of drug-resistant strains necessitate the need of novel drug targets to treat the disease. The present invention describes a novel assay method of identifying candidate compounds as anti-malarials based on the property of binding to plasmodial parasite 90 kDa heat shock protein.

REFERENCES:
patent: 03/050295 (2003-06-01), None
Jendoubi et al., 1985. Characterization of one polypeptide antigen potentially related to protective immunity against the blood infection byPlasmodium falciparumin the squirrel monkey. J. Immunology 134: 1941-1954.
Banumathy et al., 2002. Host charperones are recruited in membrane-bound complexes byPlasmodium falciparum. J. Biol. Chem. 277: 3902-3912.
Bonnefoy et al., 1994. Molecular characterization of the heat shock protein 90 gene of the human malaria parasitePlasmodium falciparum. Mol. Biochem. Parasitol. 67: 157-170.
Chiosis et al., 2001. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem. & Biol. 8: 289-299.
DeBoer et al., 1970. Geldanamycin, a new antibiotic. J. Antibiotics 23: 442-447.

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